Cytochrome P 450 and the arachidonate cascade 1 JORGE
نویسنده
چکیده
0892-h61R/q2/fl00E.fl7l 1/401 cft ( FAcIR ABSTRACT Arachidonic acid and many products of the arachidonate cascade serve as substrates for cytochrome P450-mediated metabolism via allylic oxidation, omega hydroxylation, and epoxygenation as well as peroxide rearrangement. Defining the physiological importance of these metabolites is an area of intense research interest. Cytochrome P450-catalyzed reactions play prominent roles in multiplying the structural and functional diversity of the arachidonate metabolic cascade. Capdevila, J. H.; Falck, J. R.; Estabrook, R. W. Cytochrome P450 and the arachidonate cascade. FASEBJ. 6: 731-736; 1992.
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